Many recent studies have shown the interest and potential of white cells in the inflammatory cascade, as a corollary, a prominent action in the early days of stimulation of osseo-progenitor cells. (Omar & Thomsen, Biomaterials, 2012, Kawazoe T, Cell. Transplant 2012)
It was therefore natural to try to capture the whole amount of monocytes in the PRF, to make it more active in stimulating bone grafts, but also to turn to a more rapid transformation of monocytes into macrophages to increase the effect bone stimulation.
This is done with the A-PRF™ or Advanced-PRF™.
The tubes, the centrifuge rpm and time of spin.
The first results of our research, conducted at the Laboratory of Clarion Research Group, Pennsylvania University (USA) and Repair-Lab, Institute of Pathology, Johannes Gutenberg University, Mainz (Germany) show a release of BMP-2 (Bone Morphogenetic Protein), and BMP-7. These studies also show a greater release of VEGF. Obviously, this release is from the monocytes.
A specific tube that was developed following our scientific research and certified as Medical Device is the tube A-PRF™ +.
This tube is the only authorized at this moment. Conventional tubes being used far tubes for laboratory tests and now non-regulatory. The tube A-PRF™ + is now available in sterile packed (May, 2013)
The first clinical data and results are very exciting!
Many scientific studies are underway: The results will be published shortly. But the presence of BMP in sufficient quantity, already provides the A-PRF ™ a future by providing practitioners with a very powerful product for bone reconstruction and a still affordable
Education: The knowledge level of the teachers is not always at a good level. Dr Choukroun has already launched the concept of the PRF and A-PRF label education. This label is given to all practitioners who wish to be updated and to acquire the necessary knowledge to provide high quality education. Contact us to get the label.